Drug used to treat peptic ulcer desease

 There are three major causative factors are recognized:

1.Gram negative Helicobacter pylori

2.Increased Hcl secretion

3. Inadequate mucosa defence against gastric acid

Treatment:

1. Antimicrobial agent:

-Amoxicillin

-Bismuth compound 

-Clarithromycine

-Metronidazole 

-Tetracycline 

2.H2 -receptor blockers

-Cimetidine

-Famotidine

-Nizatidine

-Ranitidine 

3.proton pump inhibitors:

-Esomeprazole

-Lansoprazole

-Omeprazole

-Pantoprazole

-Rabeprazole

4.Prostagladine:

-misoprostol

5.Antimuscarinic agents:

-Dicyclomine

6.Antacid:

-Aluminum hydroxide

-Calcium carbonate

-Magnesium hydroxide

-Sodium bicarbonate 

7.Mucosal protective agent

-Colloidal bismuth

-Sucralfate

Important  notes:

-Cimentidine can potentiate the action of drugs like warferin,dizepam,phenytoin,quinine,carbamazipine,theophylline, imipramine therefore precautions  should take before administration of Cementide. 


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